Table 3

Characteristics of included studies

1994–19951999–20002004–20052009–20102014–2015Total
Number of trials included264546454520
Mean STRICTA score (min–max)4.27 (2.21–6.24)4.29 (2.14–6.33)4.53 (2.715–7)5.06 (2.48–7)5.53 (3.48–7)4.78 (2.14–7)
SD of STRICTA score0.850.880.900.960.901.02
Mean CONSORT score (min–max)1.01 (0–3)1.70 (0–5)2.61 (0–5)2.72 (0–5)3.32(1 – 5)2.39 (0–5)
SD of CONSORT score0.841.471.391.511.411.57
Mean STRICTA+CONSORT score (min–max)5.29 (3.21–7.6)5.99 (2.14–11)7.14 (4.17–11.5)7.78 (3.48–12)8.85 (4.48–12)7.17 (2.14–12)
SD of STRICTA+CONSORT score1.211.961.812.051.992.22
Trial setting: inpatient/outpatient (%)2/24 (7.7/92.3)7/38 (15.6/84.4)11/35 (23.9/76.1)10/35 (22.2/77.8)11/34 (24.4/75.6)41/166 (19.8/80.2)
Trial population age: paediatric/adult (%)3/23 (11.5/88.5)1/44 (2.2/97.8)0/46 (0/100)7/38 (15.6/84.4)0/45 (0/100)11/196 (5.3/94.7)
Endorsing STRICTA: yes/no (%)4/22 (15.4/84.6)2/43 (4.4/95.6)3/43 (6.5/93.5)24/21 (53.3/46.7)21/24 (46.7/53.3)54/153 (26.1/73.9)
Endorsing CONSORT: yes/no (%)10/16 (38.5–61.5)22/23 (48.9/51.1)24/22 (52.2/47.8)30/15 (66.7/33.3)29/16 (64.4/35.6)115/92 (55.6/44.4)
Average number of authors (min–max)3.56 (1 - 8)4.31 (1 - 9)5.41 (1 - 13)6.11 (2 - 15)6.57 (1 - 17)5.37 (1 - 17)
Average number of participants randomised (min–max)80.80 (8 – 568)70.06 (12 – 238)100.13 (10 – 386)84.91 (10 – 638)95.47 (20 – 517)86.80 (8 – 683)