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Acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) versus acupuncture or NSAIDs alone for the treatment of chronic neck pain: an assessor-blinded randomised controlled pilot study
  1. Jae-Heung Cho1,
  2. Dong-Hyun Nam2,
  3. Ki-Tack Kim3,
  4. Jun-Hwan Lee1
  1. 1Department of Korean Rehabilitation Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea
  2. 2Department of Biofunctional Medicine and Diagnostics, Kyung Hee University Hospital at Gangdong, Seoul, Korea
  3. 3Department of Orthopedic Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Korea
  1. Correspondence to Dr Jun-Hwan Lee, Department of Korean Rehabilitation Medicine, Kyung Hee University Hospital at Gangdong, #149, Sangil-dong, Gangdong-gu, Seoul 134-727, Korea; omdjun{at}kiom.re.kr

Abstract

Objective To investigate the feasibility and sample size required for a full-scale randomised controlled trial of the effectiveness of acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) for chronic neck pain compared with acupuncture or NSAID treatment alone.

Methods A total of 45 patients with chronic neck pain participated in the study. For 3 weeks the acupuncture with NSAIDs treatment group took NSAIDs (zaltoprofen, 80 mg) daily while receiving acupuncture treatment three times a week. The acupuncture treatment group received treatment three times a week and the NSAID treatment group took NSAIDs daily. The primary outcomes were to determine the feasibility and to calculate the sample size. As secondary outcomes, pain intensity and pain-related symptoms for chronic neck pain were measured.

Results With regard to enrolment and dropout rates, 88.2% of patients consented to be recruited to the trial and 15.6% of participants were lost to follow-up. The sample size for a full-scale trial was estimated to be 120 patients. Although preliminary, there was a significant change in the visual analogue scale (VAS) for neck pain intensity between the baseline measurement and each point of assessment in all groups. However, there was no difference in VAS scores between the three groups.

Conclusions This pilot study has provided the feasibility and sample size for a full-scale trial of acupuncture with NSAIDs for chronic neck pain compared with acupuncture or NSAID treatment alone. Further research is needed to validate the effects of acupuncture with NSAIDs.

Clinical Trial Registration NIH ClinicalTrials.gov NCT01205958.

  • ACUPUNCTURE
  • PAIN MANAGEMENT
  • COMPLEMENTARY MEDICINE

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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