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Laser acupuncture in the treatment of burning mouth syndrome: a pilot study
  1. V Brailo1,
  2. A Bosnjak2,
  3. V Vucicevic Boras1,3,
  4. A Kvesic Jurisic4,
  5. I Pelivan4,
  6. S Kraljevic-Simunkovic3,4
  1. 1Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
  2. 2Department of Periodontology, School of Medicine, Croatia
  3. 3Clinical Hospital Center Zagreb, Croatia
  4. 4Department of Prosthodontics, School of Dental Medicine, University of Zagreb, Croatia
  1. Correspondence to Dr Vucicevic Boras Vanja, Department of Oral Medicine, School of Dental Medicine, University of Zagreb 10 000, Croatia; boras{at}

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According to the definition of the International Headache Society, burning mouth syndrome (BMS) is an intraoral burning sensation for which no dental or medical cause could be identified.1 Recently, various authors suggested that acupuncture might be effective in patients with BMS.2–4 In ancient acupuncture texts, it was stated that ‘the Spleen opens in the mouth and the Heart in the tongue’, so the organs Spleen and Heart are traditionally involved in BMS. Spleen and Heart are also the organs that are most involved in depression, hence the traditional connection between BMS and depression, stress and anxiety.5

The aim of this study was to evaluate whether laser acupuncture was effective in patients with burning mouth syndrome, as no satisfactory treatments for this condition are available and patients with the condition may experience substantial disturbance to everyday life.

The Ethical Committee of the Zagreb School of Dentistry approved this study and participants signed informed consent. There were 16 participants (2 men and 14 women); ages ranged from 36 to 87 years (mean age 70.9 years). Symptom duration was from 3 to 180 months (average 41.3 ± 63.7 months). BMS diagnostic criteria were according to Scalla et al.6 None of the patients had any identified habit that might lead to burning symptoms, or candidal infection. All patients had results of routine blood tests (including iron and ferritin levels) within normal ranges. None used medication that might lead to burning mouth symptoms. Previously, all patients had been treated unsuccessfully with clonazepam.

Treatments consisted of eight sessions of laser acupuncture, each lasting 15 min, on alternate days. The following points were treated: from ST1 to ST3, ST4, ST5, LI4, LU7, GV14, CV17, SP10, SP9 and SP6. The laser wavelength was 660 nm, output power 50, dose 1.5–2.0 J/cm2 (Medio Laser Kombi, Iskra Medical, Slovenia; Burning intensity was recorded by use of a visual analogue scale (VAS) from 0–10 before and after the course of treatments.

The difference in burning intensity was tested by use of t test for dependent samples and values <0.05 were considered as significant. Demographic and clinical data for the patients are presented in table 1. The average decrease in burning symptoms after the acupuncture treatment was 55.2%. All patients experienced a decrease in burning symptoms that was reflected in the lower VAS scores.

Table 1

Demographic and clinical characteristics of patients

Burning mouth syndrome remains an enigmatic condition, currently considered as a neuropathy affecting the trigeminal nerve. Accordingly, most of the available treatments are unsatisfactory. Sardella et al2 gave 20 sessions of acupuncture treatment to 10 patients with BMS over 8 weeks and found VAS score decreased on average by 0.99 (maximum 2.1/minimum 0.1), which was statistically significant. They also reported that there was no significant improvement in the quality of life scores, although patients seem to cope better with their oral symptoms. These findings2 are in concordance with our results, and all our patients experienced a decrease in burning symptoms with an average decrease of 55.2%. It is important to note that our patients had only eight sessions.

Scardina et al3 reported that acupuncture was beneficial in patients with BMS, with mean VAS pain level reduced from 8 to 3. Sardella et al5 and Scardina et al3 both used much longer treatment periods (8 weeks and 6 months, respectively). Our patients finished treatment after 3 weeks, which is more convenient for them. Satko et al4 also reported successful outcomes when treating patients with BMS by use of acupuncture. We used laser acupuncture as it is less painful than the standard needle acupuncture and the result of this pilot study suggest that laser acupuncture might be useful in patients with BMS, although randomised controlled trials are necessary to validate these findings.


The authors wish to thank Mrs Slavica Kraljevic for her excellence in performing laser acupuncture sessions. This work was supported by the Croatian Ministry of Science, Technology and Sport (project number 065-0650445-0485).


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  • Contributors VB: analysis and interpretation of data. AB: final approval of the version to be published. VVB: drafting the article. AKJ: substantial contributions to conception and design. IP: acquisition of data. SK-S: substantial contributions to conception and design.

  • Competing interests None.

  • Ethics approval Ethical Committee of the School of Dentistry in Zagreb, Croatia.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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