Article Text

Immediate effects of acupuncture on the mechanosensitivity of the median nerve: an exploratory randomised trial
  1. Nuno Morais1,
  2. Henry Johannes Greten2,3,
  3. Maria João Santos2,
  4. Jorge Pereira Machado2
  1. 1 Department of Health Technologies, School of Health Sciences (ESSLei – IPL), Instituto Politecnico de Leiria, Leiria, Portugal
  2. 2 Instituto de Ciencias Biomedicas Abel Salazar (ICBAS – UP), Universidade do Porto, Porto, Portugal
  3. 3 Heidelberg School of Traditional Chinese Medicine, Heidelberg, Germany
  1. Correspondence to Dr Nuno Morais, RuaEngenheiro Duarte Pacheco, 9C, Fração AC 3850-040 Albergaria-a-Velha, Portugal; rpgnunomorais{at}


Background Acupuncture appears to reduce the mechanosensitivity of peripheral nerves in animal models; yet, this possibility has not been demonstrated in humans.

Objectives The main objective of this exploratory trial was to evaluate the immediate effects of acupuncture on the mechanosensitivity of the median nerve, measured by the elbow extension range-of-motion (EE–ROM) at pain onset and maximum tolerance during the upper limb neurodynamic test 1 (ULNT1). Additional objectives were to test the effects of two different points in ULNT1 responses and critically appraise pre-/post-intervention changes for conducting future research.

Methods Thirty-one asymptomatic individuals, randomly assigned to the PC group (n=14) or the LU group (n=17) by the coin flip procedure, underwent acupuncture (leopard spot needling) at PC5 or LU5’’, respectively. Two-way mixed-model analysis of variance (ANOVA) with time (pre-intervention vs post-intervention) as the within-subject factor and group (PC vs LU) as the between-subject factor, plus time×group interaction, were used to determine the effects of acupuncture therapy on EE–ROM at pain onset and maximum tolerance during ULNT1.

Results At baseline there were no differences between groups (p>0.05). After acupuncture, mean EE–ROM increased 3.1° at pain onset (p=0.029, η2 p=0.154) and 5.6° at maximum tolerance (p=0.002, η2 p=0.277) with no differences between groups (p>0.05, η2 p<0.01).

Conclusion Immediately after acupuncture, the mechanosensitivity of the median nerve appears to be reduced as observed by an increase in EE–ROM during the ULNT1. Further studies are needed to confirm these preliminary findings.

Trial registration number NCT02150915; Post-results.

  • acupuncture
  • pain management
  • musculoskeletal
  • rehabilitation medicine

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  • Contributors NM contributed to the conception and design of the work, acquisition, analysis, and interpretation of the data, and drafted the manuscript. HJG contributed to the conception and design of the work and interpretation of the data. MJS contributed to the design of the work and acquisition of the data. JPM contributed to the design of the work and acquisition of the data. All authors revised the work critically for important intellectual content, and approved the final version of the manuscript.

  • Competing interests None declared.

  • Ethics approval Ethics Committee of the Institute of Biomedical Sciences Abel Salazar of University of Porto (ICBAS–UP, project# 064/2014).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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