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Effect of acupuncture on salivary immunoglobulin A after a bout of intense exercise
  1. Yuichi Matsubara1,
  2. Kazuhiro Shimizu1,2,
  3. Yuko Tanimura1,
  4. Toshikazu Miyamoto1,
  5. Takayuki Akimoto3,4,
  6. Ichiro Kono1
  1. 1Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
  2. 2Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan
  3. 3Laboratory of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  4. 4Institute for Biomedical Engineering, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokyo, Japan
  1. Correspondence to Dr Ichiro Kono, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan; kono{at}

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To the Editor: We would like to thank Professor Wiwanitkit for his interest and thoughtful comments regarding our manuscript. We think it has been recognised that the change could be normal physiological response in the subjects because the response is reproducible among a wide range of subjects with similar exercise in previous papers.1,,4 We agree that there are few data on the background of the subjects such as showing in table 1.

Table 1

Subjects' characteristics

In terms of the quality control of laboratory determination for salivary immunoglobulin A, we are sure it should be accurate as previously reported from our group.5,,7 This previous study showed that the interassay coefficient of variation of enzyme-linked immunosorbent assay (ELISA)method was 6.2%.5

We completely agree with the final point that the complete study on the effect of acupuncture on all physiological aspects is needed. Up to now, there are very few studies to attempt to examine effects of acupuncture treatment on immune function. Although, it is not considered to meet the criteria of the prohibited list by the World Anti-Doping Agency at this point.

Therefore, the comments highlighted by Professor Wiwanitkit are important and stimulating in our comprehension of the positive impacts of acupuncture treatment on exercise immunology.


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  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was approved by the Ethical Committees of the Institute of Health and Sport Sciences and the Institute of Clinical Medicine of University of Tsukuba.

  • Provenance and peer review Commissioned; not externally peer reviewed.

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