Table 1

Characteristics of the included studies

AuthorsNumberAge (years)InterventionsDurationOutcome measurements
T/CTCTC(weeks)
Dickman 200711 15/1552.7±10.848.9±8.1EA+WMOmeprazole 20 mg twice daily41. Symptom scores;
2. SF-36 score;
3. Adverse events
Feng 201615 30/3048.9±16.0744.7±15.26MARabeprazole 20 mg as needed41. Global symptom improvement;
2. RDQ scores;
SAS;
SDS
Guo 200724 31/3022–6221–63MA+WMFamotidine 20 mg twice daily, domperidone 10 mg three times daily5Global symptom improvement
Lan 200823 40/3645.3±16.744.1±14.5MA+WMLansoprazole 30 mg twice daily, domperidone 10 mg threee times daily4Global symptom improvement
Liu 200725 59/6044.6±14.2645.8±12.96MAOmeprazole 20 mg once daily81. Global symptom improvement;
2. Symptom score;
3. Recurrence rate;
4. Endoscopic grading score;
5. Adverse events
Liu 201517 34/3440.4±4.3642.3±5.01MA+WMOmeprazole 40 mg once daily, itopride 50 mg three times daily51. Global symptom improvement;
2. Adverse event
Wang 201516 40/2043.6±1.843.4±1.5EARabeprazole 20 mg once daily21. Global symptom improvement;
2. RDQ score;
3. Gastrin level
Xiang 201418 31/3144.4±24.6744.1±25.25EAMosapride 5 mg three times daily41. Global symptom improvement;
2. Symptom scores
Yu 201122 28/2842.343.5MA+WMLansoprazole 30 mg once daily, mosapride 5 mg three times daily41. Global symptom improvement;
2. Recurrence rate
Zhang 2012a21 120/12043±942±13EAPantoprazole 20 mg twice daily, mosapride 5 mg three times daily61. Oesophageal impedance-pH monitoring;
2. Global symptom improvement;
3. Endoscopic grading score;
Symptom score;
4. SF-36 scores;
5. Adverse events
Zhang 2012b20 122/12342.4±11.741.7±18.2EAOmeprazole 20 mg twice daily, mosapride 5 mg three times daily, amitriptyline 25 mg twice daily61. Oesophageal impedance-pH monitoring;
2. Global symptom improvement;
3. Endoscopic grading score;
4. Symptom score;
5. SF-36 scores;
6. Adverse events
Zhang 201319 50/5041.139.8EA+WMPantoprazole 40 mg once daily51. Global symptom improvement;
2. Recurrence rate;
3. Adverse events
  • C, control group; EA, electroacupuncture; MA, manual acupuncture; RDQ, Roland-Morris isability Questionnaire; SAS, Self-rating Anxiety Scale; SDS, Self-rating Depression Scale; T, trial group; SF-36, 36-item Short Form Health Survey; WM, Western medicine.