Table 2

Insomnia Severity Index (ISI) change scores by Taditional Chinese Medicine diagnosis and comorbid anxiety and depression

Heart-kidney non-interaction (n=80)Deficiency of both the heart and spleen (n=61)Liver-qi stagnation transforming into fire (n=41)Hyperactivity of fire due to yin deficiency (n=23) χ 2 p Value
T0-T1
ISI total change score4.9±5.13.7±4.25.7±5.34.8±6.50.35
ISI change score ≥823 (28.8)13 (21.3)15 (36.6)3 (13.0)5.350.15
Depress –
(n=39)
Depress +
(n=41)
Depress –
(n=41)
Depress +
(n=20)
Depress –
(n=15)
Depress +
(n=26)
Depress –
(n=12)
Depress +
(n=11)
ISI total change score
ISI change score ≥8
4.2±5.3
7 (17.9)
5.5±4.8
16 (39.0)*
3.3±4.2
8 (19.5)
4.6±4.2
5 (25.0)
4.9±4.8
4 (26.7)
6.2±5.7
11 (42.3)
2.9±6.6
1 (8.3)
6.8±6.6
2 (18.2)
7.150.005
0.41
Anxiety –
(n=37)
Anxiety +
(n=43)
Anxiety –
(n=32)
Anxiety +
(n=29)
Anxiety –
(n=13)
Anxiety +
(n=28)
Anxiety –
(n=12)
Anxiety +
(n=11)
ISI total change score
ISI change score ≥8
4.8±5.5
9 (24.3)
4.9±4.7
14 (32.6)
2.9±4.5
7 (21.9)
4.6±3.7
6 (20.7)
6.3±6.2
5 (38.5)
5.4±5.0
10 (35.7)
4.6±7.8
2 (16.7)
5.0±5.1
1 (9.1)
6.260.42
0.51
  • T0, baseline; T1, 1 week post-treatment. Depress ±, absence or presence of depression. Values are expressed as mean±SD or n (%). p values based on Kruskal-Wallis or χ2 test. *χ2=4.3, p=0.04 (within-pattern comparison).