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Effects of auricular acupressure combined with low-calorie diet on the leptin hormone in obese and overweight Iranian individuals
  1. Mahsa Darbandi1,
  2. Sara Darbandi1,
  3. Majid Ghayor Mobarhan1,2,
  4. Ali Akbar Owji3,
  5. Baxiao Zhao4,
  6. Kambiz Iraji5,
  7. Hamid Abdi1,
  8. Mehdi Saberfiroozi6,
  9. Mohsen Nematy1,2,
  10. Mohammad Safarian1,2,
  11. Mohammad Reza Parizadeh1,
  12. Parisa Abbasi1,
  13. Masoud Salehmoghadam1,
  14. Majid Fardaei7,
  15. Mohammad Hossein Dabbaghmanesh8,
  16. Gordon Ferns9,
  17. Pooneh Mokarram3,6
  1. 1Department of Medicine, Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2Cardiovascular Research Center, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
  5. 5Department of Resource Development and Management, Shiraz University of Medical Sciences, Iran
  6. 6Gastroenterohepatology Research Center, Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7Department of Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8Endocrine Research Center, Department of Internal Medicine, Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9Institutes for Science and Technology in Medicine, Keele University, Hartshill, UK
  1. Correspondence to Pooneh Mokarram, Department of Biochemistry, School of Medicine and Gastroenterohepatology Research Center, Nemazee Hospital School of Medicine, Shiraz University of Medical Sciences, 7134853185, Shiraz, Iran; mokaram2{at}gmail.com.

Abstract

Background Human leptin is a peptide hormone that is released from white adipocytes. The absence of leptin or its receptor leads to uncontrolled food intake, leading to obesity. In the present work, the effects of auricular acupressure combined with low-calorie diet on the leptin hormone level were investigated.

Methods Volunteers (n=86) with body mass indices (BMI) between 25 and 45 kg/m2 were randomised into a case (n=43) or a control (n=43) group. Participants in each group received a low-calorie diet for 6 weeks. The case group was treated with auricular acupressure and the control group received a sham procedure. Plasma leptin levels, body fat mass, body weight and BMI were measured before and after treatment.

Results Participants who received auricular acupressure showed significant reductions in their plasma leptin levels (18.57%, p<0.01) as well as in their body fat mass (4%, p<0.05). These changes were not observed in the control group. The reduction in leptin was significantly greater in the acupressure group than the controls.

Conclusions Auricular acupressure combined with a low-calorie diet significantly reduced plasma levels of leptin. However, the mechanism of this reduction is not clear.

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Footnotes

  • MD and SD contributed equally to this work.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the Ethics Committee of Mashhad University of Medical Sciences.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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