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Direct current electrical stimulation of acupuncture needles for peripheral nerve regeneration: an exploratory case series
  1. Motohiro Inoue1,
  2. Yasukazu Katsumi2,
  3. Megumi Itoi3,
  4. Tatsuya Hojo4,
  5. Miwa Nakajima1,
  6. Suzuyo Ohashi3,
  7. Yuki Oi1,
  8. Hiroshi Kitakoji1
  1. 1Department of Clinical Acupuncture and Moxibustion, Meiji University of Integrative Medicine, Kyoto, Japan
  2. 2Department of Orthopedic Surgery, Uji-Takeda Hospital, Kyoto, Japan
  3. 3Department of Orthopedic Surgery, Meiji University of Integrative Medicine, Kyoto, Japan
  4. 4Faculty of Health and Sports Science, Doshisha University, Kyoto, Japan
  1. Correspondence to Dr Motohiro Inoue, Licensed Acupuncturist, Department of Clinical Acupuncture and Moxibustion, Meiji University of Integrative Medicine, Honoda, Hiyoshi-cho, Nantan-city, Kyoto 629-0392, Japan; mo_inoue{at}


Objective To examine the therapeutic effect of a novel therapeutic method based on electroacupuncture with intermittent direct current (DCEA) and associated adverse events in patients with peripheral nerve damage and a poor clinical prognosis.

Methods In seven older patients with peripheral nerve damage (neurapraxia 2, axonotmesis 4, neuromesis 1), an acupuncture needle connected to an anode electrode was inserted proximal to the site of the injury along the route of the nerve, while the cathode electrode was inserted into the innervated muscle, and DCEA was performed (100 Hz for 20 min, weekly). Muscular paralysis was evaluated weekly with manual muscle testing, the active range of motion of joints related to the muscular paralysis and, when necessary, needle electromyography. Adverse events were also recorded during the course of the treatment.

Results Complete functional recovery was observed in the two cases with neurapraxia and two with axonotmesis, while one axonotmesis case achieved improvement and the other showed reinnervation potential without functional recovery. No improvement was observed in the neurotmesis case. Pigmentation of the skin where the anode needle was inserted occurred in three cases. Although there was no definite causal link, one case showed excessive formation and resorption of bone in the area close to the cathode needle site.

Discussion Accelerated nerve regeneration caused by DCEA may contribute to recovery. The skin pigmentation and callus formation suggest that the shape of the anode electrode, current intensity and other factors should be examined to establish a safer treatment method.

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  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the ethics committee of the Meiji University of Integrative Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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