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To the Editor: We would like to thank Professor Wiwanitkit for his interest and thoughtful comments regarding our manuscript. We think it has been recognised that the change could be normal physiological response in the subjects because the response is reproducible among a wide range of subjects with similar exercise in previous papers.1,–,4 We agree that there are few data on the background of the subjects such as showing in table 1.
In terms of the quality control of laboratory determination for salivary immunoglobulin A, we are sure it should be accurate as previously reported from our group.5,–,7 This previous study showed that the interassay coefficient of variation of enzyme-linked immunosorbent assay (ELISA)method was 6.2%.5
We completely agree with the final point that the complete study on the effect of acupuncture on all physiological aspects is needed. Up to now, there are very few studies to attempt to examine effects of acupuncture treatment on immune function. Although, it is not considered to meet the criteria of the prohibited list by the World Anti-Doping Agency at this point.
Therefore, the comments highlighted by Professor Wiwanitkit are important and stimulating in our comprehension of the positive impacts of acupuncture treatment on exercise immunology.
Competing interests None.
Patient consent Obtained.
Ethics approval This study was approved by the Ethical Committees of the Institute of Health and Sport Sciences and the Institute of Clinical Medicine of University of Tsukuba.
Provenance and peer review Commissioned; not externally peer reviewed.
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